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pentobarbital will reduce the level or influence of ritonavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will reduce the extent or influence of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Lack of, or reduced response to tofacitinib may perhaps manif